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Trends Pharmacol Sci. 2006 Jun;27(6):338-44. Epub 2006 May 11.

Emerging cancer therapeutic opportunities target DNA-repair systems.

Author information

1
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. jding@mail.shcnc.ac.cn

Abstract

DNA-damaging agents have a central role in non-surgical cancer treatment. The balance between DNA damage and repair determines the final therapeutic consequences. An elevated DNA-repair capacity in tumor cells leads to drug or radiation resistance and severely limits the efficacy of these agents. Interference with DNA repair has emerged as an important approach in combination therapy against cancer. Anticancer targets in DNA-repair systems have emerged, against which several small-molecule compounds are currently undergoing clinical trials.

PMID:
16697054
DOI:
10.1016/j.tips.2006.04.007
[Indexed for MEDLINE]

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