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Cell Mol Immunol. 2006 Apr;3(2):87-95.

The T-box transcription factor T-bet in immunity and autoimmunity.

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Inflammation, Autoimmunity and Transplantation Research, Roche Palo Alto, Palo Alto, CA 94304, USA.


The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1 (Th1) immunity, appear to require T-bet, at least as judged in mouse models. This review summarizes a current understanding of T-bet's role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention.

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