Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell Endocrinol. 2006 Jun 27;252(1-2):154-9. Epub 2006 May 9.

Human embryonic stem cells as a cellular model for human disorders.

Author information

1
Department of Genetics, Life Science Institute, The Hebrew University, Jerusalem 91904, Israel.

Abstract

Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.

PMID:
16690205
DOI:
10.1016/j.mce.2006.03.034
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center