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Reumatizam. 2005;52(2):61-6.

[Nonsteroidal antirheumatics and the kidney].

[Article in Croatian]

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Odjel za nefrologiju, KB Dubrava, Av. G. Suska 6, 10000 Zagreb.


The renal side effects of nonsteroidal anti-inflammatory drugs are very often and could be seen in 5% of patients who are treated with this drugs. These side effects could be separated in 5 clinical syndromes: 1. acute renal failure, 2. acute interstitial nephritis with nephrotic syndrome, 3. electrolyte and fluid disorders, 4. hypertension and 5. analgesic nephropathy. There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).

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