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J Perinatol. 2006 Aug;26(8):476-80. Epub 2006 May 11.

Work of breathing using high-flow nasal cannula in preterm infants.

Author information

1
Division of Neonatology, Department of Pediatrics, The Children's Regional Hospital at Cooper University Hospital, Camden, NJ 08103, USA. saslow-judy@cooperhealth.edu

Abstract

OBJECTIVE:

To compare the work of breathing (WOB) in premature neonates supported with high-flow nasal cannula (HFNC) and nasal continuous positive airway pressure (NCPAP).

STUDY DESIGN:

Eighteen preterm neonates <2.0 kg on HFNC or NCPAP support were studied in a random order. A ventilator was used to deliver 6 cm H2O of NCPAP with nasal prongs. High-flow nasal cannula delivered with Vapotherm (VAPO) at 3, 4 and 5 l/min was used. Tidal ventilation was obtained using respiratory inductance plethysmography calibrated with face-mask pneumotachography. An esophageal balloon estimated pleural pressure from which changes in end distending pressure were calculated. Inspiratory, elastic and resistive WOB and respiratory parameters were calculated.

RESULTS:

No differences were found in the WOB for all settings. Changes in end distending pressure did not vary significantly over all device settings except VAPO at 5 l/min.

CONCLUSION:

In these preterm infants with mild respiratory illness, HFNC provided support comparable to NCPAP.

PMID:
16688202
DOI:
10.1038/sj.jp.7211530
[Indexed for MEDLINE]
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