Format

Send to

Choose Destination
See comment in PubMed Commons below
Spine (Phila Pa 1976). 2006 May 15;31(11):1247-52.

Determinants of spontaneous resorption of intervertebral disc herniations.

Author information

1
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. reijo.autio@mhso.fi

Abstract

STUDY DESIGN:

A follow-up of disc herniation (herniated nucleus pulposus [HNP]) resorption on magnetic resonance imaging (MRI).

OBJECTIVE:

To assess the determinants of resorption of HNP.

SUMMARY OF BACKGROUND DATA:

Neovascularization in the outermost areas of HNP, presenting as an enhancing rim in gadolinium diethylenetriamine pentaacetic acid MR images, is thought to be a major determinant of spontaneous resorption of HNP.

METHODS:

Patients with HNP-induced sciatica at baseline were rescanned at 2 months (N = 74) and after 12 months (N = 53). The volume of HNP (mm), thickness (mm) and extent (%) of enhancement, and the degree of HNP migration (Komori classification) were analyzed. Repeated measures analysis of covariance was used in statistical analysis.

RESULTS:

Significant resorption of HNP occurred from baseline to 2 months, although the resorption rate was more pronounced over the whole 1-year follow-up. Higher baseline scores of rim enhancement thickness, higher degree of HNP displacement in the Komori classification, and age category 41-50 years were associated with a higher resorption rate. Thickness of rim enhancement was a stronger determinant of spontaneous resorption than extent of rim enhancement. Clinical symptom alleviation occurs concordantly with a faster resorption rate.

CONCLUSIONS:

MRI is a useful prognostic tool for identifying patients with HNP-induced sciatica with a benign natural course.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center