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Cell Cycle. 2006 May;5(9):958-62. Epub 2006 May 1.

Evidence for extrinsic exonucleolytic proofreading.

Author information

1
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA.

Abstract

Exonucleolytic proofreading of DNA synthesis errors is one of the major determinants of genome stability. However, many DNA transactions that contribute to genome stability require synthesis by polymerases that naturally lack intrinsic 3' exonuclease activity and some of which are highly inaccurate. Here we discuss evidence that errors made by these polymerases may be edited by a separate 3' exonuclease, and we consider how such extrinsic proofreading may differ from proofreading by exonucleases that are intrinsic to replicative DNA polymerases.

PMID:
16687920
PMCID:
PMC2907748
DOI:
10.4161/cc.5.9.2736
[Indexed for MEDLINE]
Free PMC Article
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