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Curr Opin Genet Dev. 1991 Oct;1(3):370-7.

Ras-regulated signaling processes in Saccharomyces cerevisiae.

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Department of Molecular Biology, Princeton University, New Jersey 08544.


Molecular genetics has proved quite successful in identifying the components of RAS-mediated signal transduction in the yeast Saccharomyces cerevisiae and in defining the nature of their interactions. Recently, the emphasis has shifted to a biochemical approach as the processes of guanine nucleotide exchange, GTPase stimulation activity and posttranslational modification of Ras proteins have all been reproduced in vitro.

[Indexed for MEDLINE]

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