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Mol Pharm. 2006 Jan-Feb;3(1):62-9.

Scientific perspectives on drug transporters and their role in drug interactions.

Author information

1
Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA.

Abstract

Recently, increased interest in drug transporters and research in this area has revealed that drug transporters play an important role in modulating drug absorption, distribution, and elimination. Acting alone or in concert with drug metabolizing enzymes they can affect the pharmacokinetics and pharmacodynamics of a drug. This commentary will focus on the potential role that drug transporters may play in drug-drug interactions and what information may be needed during drug development and new drug application (NDA) submissions to address potential drug interactions mediated by transporters.

PMID:
16686370
DOI:
10.1021/mp050095h
[Indexed for MEDLINE]

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