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Ann Pharmacother. 2006 Jun;40(6):1158-61. Epub 2006 May 9.

The role of vitamin D in multiple sclerosis.

Author information

1
Drug Information Service, Skaggs School of Pharmacy, College of Health Professions and Biomedical Sciences, The University of Montana, Missoula, 59812-1522, USA. sherrill.brown@umontana.edux

Abstract

OBJECTIVE:

To evaluate the literature about the role of vitamin D in the prevention and treatment of multiple sclerosis (MS).

DATA SOURCES:

MEDLINE (1966-April 2006) and International Pharmaceutical Abstracts (1970-April 2006) searches were performed. In addition, pertinent references from identified articles were obtained. Key search terms included vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, and multiple sclerosis.

DATA SYNTHESIS:

Vitamin D supplementation prevented the development and progression of experimental autoimmune encephalitis, an animal model of MS, in mice. A large, prospective, cohort study found that vitamin D supplementation was associated with a 40% reduction in the risk of developing MS. Four small, noncontrolled studies suggested that vitamin D supplementation may decrease exacerbation of MS symptoms.

CONCLUSIONS:

Vitamin D supplementation may help prevent the development of MS and may be a useful addition to therapy. However, current studies are in small populations and are confounded by other variables, such as additional vitamin and mineral supplementation.

PMID:
16684809
DOI:
10.1345/aph.1G513
[Indexed for MEDLINE]

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