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Arch Pathol Lab Med. 2006 May;130(5):712-7.

An overview of inflicted head injury in infants and young children, with a review of beta-amyloid precursor protein immunohistochemistry.

Author information

1
Cuyahoga County Coroner's Office, Cleveland, OH 44106, USA. ddolinak@hotmail.com

Abstract

CONTEXT:

Inflicted traumatic brain injury of infants and young children results in a complex array of autopsy findings. In many cases, immunostains for beta-amyloid precursor protein are used to detect axonal injury. Interpretation of the gross, microscopic, and immunostaining results requires the integration of the many facets of the individual case.

OBJECTIVE:

In this article we review the gross and microscopic findings associated with inflicted traumatic brain injury. The application and interpretation of beta-amyloid precursor protein immunostains are discussed and photomicrographs are used to illustrate immunostaining patterns.

DATA SOURCES:

The pertinent literature is integrated into a review of the subject.

CONCLUSIONS:

Inflicted traumatic brain injury often results in subdural, subarachnoid, retinal, and optic nerve sheath hemorrhage. These findings must be interpreted within the entire context of the case. Beta-amyloid precursor protein immunostains may be helpful in illustrating the traumatic nature of the injuries in some cases.

[Indexed for MEDLINE]

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