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Eukaryot Cell. 2006 May;5(5):876-9.

Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.

Abstract

Trypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and depletion of TbNoLP produces an enlarged nucleolus in which TbNopp140-containing regions disperse. The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling.

PMID:
16682465
PMCID:
PMC1459678
DOI:
10.1128/EC.5.5.876-879.2006
[Indexed for MEDLINE]
Free PMC Article

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