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Biochemistry. 2006 May 16;45(19):5939-48.

Participation of the tRNA A76 hydroxyl groups throughout translation.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520-8114, USA.

Abstract

The free 2'-3' cis-diol at the 3'-terminus of tRNA provides a unique juxtaposition of functional groups that play critical roles during protein synthesis. The translation process involves universally conserved chemistry at almost every stage of this multistep procedure, and the 2'- and 3'-OHs are in the immediate vicinity of chemistry at each step. The cis-diol contribution affects steps ranging from tRNA aminoacylation to peptide bond formation. The contributions have been studied in assays related to translation over a period that spans at least three decades. In this review, we follow the 2'- and 3'-OHs through the steps of translation and examine the involvement of these critical functional groups.

PMID:
16681365
PMCID:
PMC2522371
DOI:
10.1021/bi060183n
[Indexed for MEDLINE]
Free PMC Article
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