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Cancer Metastasis Rev. 2006 Mar;25(1):99-113.

Novel functions of TIMPs in cell signaling.

Author information

1
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA. hrckim@med.wayne.edu

Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the extracellular matrix (ECM) turnover and remodeling during normal development and pathogenesis. Increasing evidence indicates a much more complex role for TIMPs during tumor progression and angiogenesis, in addition to their regulation of MMP-mediated ECM degradation. In this article, we review both the MMP-dependent and -independent actions of TIMPs for the regulation of cell death, cell proliferation, and angiogenesis, with a particular emphasis on TIMP-1 in the regulation of tetraspanin/integrin-mediated cell survival signal transduction pathways.

PMID:
16680576
DOI:
10.1007/s10555-006-7893-x
[Indexed for MEDLINE]
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