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Nat Neurosci. 2006 Jun;9(6):735-7. Epub 2006 May 7.

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.

Author information

1
Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA. jkleim@ufl.edu

Abstract

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

PMID:
16680163
DOI:
10.1038/nn1699
[Indexed for MEDLINE]
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