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Clin Neurophysiol. 2006 Jun;117(6):1312-8. Epub 2006 May 5.

Bilateral impairment of intracortical inhibition in delayed-onset posthemiplegic dystonia: pathophysiological implications.

Author information

1
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via de Toni, 5, 16132 Genova, Italy.

Abstract

OBJECTIVE:

To study short interval intracortical inhibition (SICI) in a rare patient with segmental dystonia of the left upper limb due to a vascular lesion in the contralateral putamen without corticospinal tract involvement.

METHODS:

Paired-pulse transcranial magnetic stimulation (TMS) was applied to both hemispheres in a conditioning-test paradigm. Six interstimulus intervals (ISIs) and 4 conditioning stimulation intensities were investigated in two separate sessions.

RESULTS:

Motor evoked potentials upon single-pulse TMS were within the normal range, whereas paired-pulse TMS revealed major changes in cortical excitability, proving that SICI was bilaterally absent.

CONCLUSIONS:

The bilateral impairment of SICI cannot be considered the cause of dystonic contractions, but just a predisposing factor.

SIGNIFICANCE:

The absence of SICI might be regarded as a condition able to promote maladaptive plastic changes triggered by focal lesions in the putamen.

PMID:
16678482
DOI:
10.1016/j.clinph.2006.03.015
[Indexed for MEDLINE]

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