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FEBS Lett. 2006 May 29;580(13):3035-41. Epub 2006 Apr 27.

Genetic networks responsive to sodium butyrate in colonic epithelial cells.

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Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Toyama 930-0194, Japan.


We performed microarray and computational gene network analyses to identify the detailed mechanisms by which sodium butyrate (SB) induces cell growth arrest and the differentiation of mouse colonic epithelial MCE301 cells. Two thousand six hundred four differentially expressed probe sets were identified in the cells treated with 2mM SB and were classified into four groups. Of these, the gradually increased group and the gradually and remarkably decreased group contained the genetic networks for cellular development and cell cycles or canonical pathways for fatty acid biosynthesis and pyrimidine metabolism, respectively. The present results provide a basis for understanding the detailed molecular mechanisms of action of SB in colonic epithelial cells.

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