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Tuberculosis (Edinb). 2006 May-Jul;86(3-4):236-46.

Vaccine potential of influenza vectors expressing Mycobacterium tuberculosis ESAT-6 protein.

Author information

1
Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg.

Abstract

We generated several attenuated recombinant influenza A vectors expressing the Mycobacterium tuberculosis early secretory antigenic target (ESAT-6) protein. The ESAT-6 protein was recently identified as one of the most promising protective antigens for cell-mediated immunity. The obtained vectors appeared to be capable of inducing ESAT-6 specific Th1 immune response in mice after intranasal immunization. We found that double immunization with two influenza vectors of different subtypes provided a significant level of protection in mice, when applied as prophylactic vaccine, as well as substantial therapeutic effect in mice with pre-established tuberculosis infection. Moreover, we found a strong synergistic effect when vaccination with Flu/ESAT-6 vectors was combined with isoniazid treatment, resulting in a dramatic reduction of bacterial load in the lungs of infected mice.

PMID:
16677861
DOI:
10.1016/j.tube.2006.01.010
[Indexed for MEDLINE]

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