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Bioorg Med Chem Lett. 2006 Jul 1;16(13):3415-8. Epub 2006 May 3.

Synthesis and SAR of novel histamine H3 receptor antagonists.

Author information

1
Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. jesudason_cynthia_d@lilly.com

Abstract

The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H(3) receptors are reported.

PMID:
16677814
DOI:
10.1016/j.bmcl.2006.04.004
[Indexed for MEDLINE]

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