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Clin Cancer Res. 2006 May 1;12(9):2657-61.

Chk2 molecular interaction map and rationale for Chk2 inhibitors.

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1
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. pommier@nih.gov

Abstract

To organize the rapidly accumulating information on bioregulatory networks related to the histone gamma-H2AX-ATM-Chk2-p53-Mdm2 pathways in concise and unambiguous diagrams, we used the molecular interaction map notation (http://discover.nci.nih.gov/min). Molecular interaction maps are particularly useful for networks that include protein-protein binding and posttranslational modifications (e.g., phosphorylation). Both are important for nearly all of the proteins involved in DNA double-strand break signaling. Visualizing the regulatory circuits underlying cellular signaling may help identify key regulatory reactions and defects that can serve as targets for anticancer drugs.

PMID:
16675556
DOI:
10.1158/1078-0432.CCR-06-0743
[Indexed for MEDLINE]
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