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Acta Neurol Scand. 2006 Jun;113(6):433-6.

Stroke after initiation of interferon-beta treatment for relapsing-remitting disseminated white matter disease.

Author information

1
Department of Neurology, University of Cologne, Germany. bbosche@pet.mpin_koeln.mpg.de

Erratum in

  • Acta Neurol Scand. 2009 Dec;120(6):453. Weber, O Z [corrected to Zaro-Weber, O].

Abstract

BACKGROUND:

Interferon-beta (INF-beta) is effective and used in reducing exacerbation frequency and disease progression in multiple sclerosis. In certain circumstances, INF-beta can lead to rare side effects.

AIMS OF THE STUDY:

We report the case of a 34-year-old female patient satisfying the McDonald criteria of multiple sclerosis without showing typical pathologic changes in cerebrospinal fluid (CSF). After introduction of INF-beta treatment, she quickly developed further progression of her disseminated neurological symptoms and finally an ischemic cerebral infarction.

METHODS:

Evaluation of the patient included arterial angiography, magnetic resonance and positron emission tomography, histopathological assessment as well as a broad spectrum of serum and CSF analysis.

RESULTS:

All diagnostic evaluations and the clinical course revealed evidences for a primary angiitis of the CNS. We discuss the possible worsening due to inappropriate INF-beta treatment in cerebral angiitis promoting severe cerebrovascular insufficiency.

CONCLUSION:

The authors suggest that all diagnostic multiple sclerosis criteria including typical CSF findings should be ascertained before INF-beta treatment is initiated.

[Indexed for MEDLINE]

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