Format

Send to

Choose Destination
J Biomed Opt. 2006 Mar-Apr;11(2):024006.

Simple device for the direct visualization of oral-cavity tissue fluorescence.

Author information

1
British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada. plane@bccrc.ca

Abstract

Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light (400 to 460 nm) is employed to excite green-red fluorescence from fluorophores in the oral tissues. Tissue fluorescence is viewed directly along an optical axis collinear with the axis of excitation to reduce inter- and intraoperator variability. This robust, field-of-view device enables the direct visualization of fluorescence in the context of surrounding normal tissue. Results from a pilot study of 44 patients are presented. Using histology as the gold standard, the device achieves a sensitivity of 98% and specificity of 100% when discriminating normal mucosa from severe dysplasia/carcinoma in situ (CIS) or invasive carcinoma. We envisage this device as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation.

PMID:
16674196
DOI:
10.1117/1.2193157
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center