Format

Send to

Choose Destination
See comment in PubMed Commons below
J R Soc Med. 2006 May;99(5):238-44.

Surgical insights into Parkinson's disease.

Author information

  • 1Oxford Functional Neurosurgery, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford OX2 6HE, UK.

Abstract

Surgery for Parkinson's disease was popularized in the mid-twentieth century before the advent of effective medical therapies. Early lesioning treatments contributed to our understanding of the functional anatomy of Parkinson's disease. Observations of the limitations and long-term complications of established pharmacological therapies for Parkinson's disease, together with major contributions from animal research to elucidate the roles of the basal ganglia in movement disorders, inspired a recent renaissance in neurosurgical interventions for Parkinson's disease including deep brain stimulation; this continues to yield much neurophysiological information. The development of potentially restorative treatment modalities, such as gene therapy, neural transplantation and nanotechnology, hold much promise for surgery, both therapeutically and in revealing further insights into Parkinson's disease pathophysiology.

PMID:
16672757
PMCID:
PMC1457758
DOI:
10.1258/jrsm.99.5.238
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center