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J Clin Microbiol. 2006 May;44(5):1844-6.

Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity.

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1
Institute for Hygiene, the National Consulting Laboratory on Hemolytic Uremic Syndrome, University Hospital Münster, Robert Koch Str. 41, and the IZKF Münster, 48149 Münster, Germany.

Abstract

We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.

PMID:
16672418
PMCID:
PMC1479162
DOI:
10.1128/JCM.44.5.1844-1846.2006
[Indexed for MEDLINE]
Free PMC Article
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