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Development. 2006 Jun;133(11):2149-54. Epub 2006 May 3.

Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.

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1
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.

Erratum in

  • Development. 2006 Jul;133(13):2595.
  • Development. 2006 Jun;133(12):2447.

Abstract

The Dkk family of secreted cysteine-rich proteins regulates Wnt/beta-catenin signaling by interacting with the Wnt co-receptor Lrp5/6. Here, we show that Dkk2-mediated repression of the Wnt/beta-catenin pathway is essential to promote differentiation of the corneal epithelial progenitor cells into a non-keratinizing stratified epithelium. Complete transformation of the corneal epithelium into a stratified epithelium that expresses epidermal-specific differentiation markers and develops appendages such as hair follicles is achieved in the absence of the Dkk2 gene function. We show that Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium.

PMID:
16672341
DOI:
10.1242/dev.02381
[Indexed for MEDLINE]
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