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Curr Hypertens Rep. 2006 May;8(2):139-43.

Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease.

Author information

1
Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 532, Little Rock, AR 72205, USA.

Abstract

Hyperlipidemia and hypertension are frequently observed in patients with coronary artery disease. It has been proposed that an interaction between low-density lipoprotein, especially its oxidized form (ox-LDL), and renin-angiotensin system (RAS) activation is a major determinant of atherogenesis. Ox-LDL accumulation in the blood vessels enhances the expression and activation of RAS components; on the other hand, activation of RAS stimulates the accumulation of LDL and its oxidation into ox-LDL in the blood vessels. Individually ox-LDL and RAS activation induce oxidative stress and inflammatory cascade, whereas their combination exerts a synergistic effect. This concept of cross-talk between ox-LDL/hyperlipidemia and RAS activation has been proven in laboratory animals. Clinical trials also suggest that blockade of hyperlipidemia and RAS may have a synergistic salutary effect on the outcome of patients with hypertension and/or manifestations of atherosclerosis. This concept needs to be evaluated further in large clinical studies.

PMID:
16672147
DOI:
10.1007/s11906-006-0010-2
[Indexed for MEDLINE]

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