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BMC Infect Dis. 2006 May 4;6:82.

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.

Author information

1
Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. h9820905@graduate.hku.hk

Abstract

BACKGROUND:

Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

METHODS:

A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS.

RESULTS:

IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility.

CONCLUSION:

IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.

PMID:
16672072
PMCID:
PMC1468415
DOI:
10.1186/1471-2334-6-82
[Indexed for MEDLINE]
Free PMC Article

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