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Org Lett. 2006 May 11;8(10):2075-7.

One-flask synthesis of dinucleoside tetra- and pentaphosphates.

Author information

  • 1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, 08854, USA.

Abstract

[reaction: see text] We report a one-flask route for the synthesis of dinucleoside tetra- and pentaphosphates, in isolated yields of 50-85%. This route relies on a mixture of P(III) and P(V) chemistries, using phosphitylation of a protected nucleoside with 2-chloro-4H-l,3,2-benzo-dioxaphosphorin-4-one (salicylchlorophosphite), followed by sequential reaction with inorganic pyrophosphate and a nucleoside 5' mono- or diphosphate.

PMID:
16671785
PMCID:
PMC2535934
DOI:
10.1021/ol060491d
[PubMed - indexed for MEDLINE]
Free PMC Article
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