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Bull Exp Biol Med. 2005 Oct;140(4):403-5.

Lanthanum potentiates GABA-activated currents in rat pyramidal neurons of CA1 hippocampal field.

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1
Brain Research Institute, Russian Academy of Medical Sciences, Moscow.

Abstract

In CA1 hippocampal pyramidal neurons, lanthanum ions increased the amplitude of GABA-activated currents and shifted the dose-dependence curve to the left, which attests to increased affinity of GABAA-receptors to GABA. The data made it possible to compare the sensitivity GABAA-receptors of pyramidal neurons and similar receptors of other cells to GABA and lanthanum.

PMID:
16671565
[Indexed for MEDLINE]

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