Format

Send to

Choose Destination
Acta Neurochir Suppl. 2006;96:364-7.

Outcome predictors for normal-pressure hydrocephalus.

Author information

1
Saarland University, Medical School, Department of Neurosurgery, Homburg-Saar, Germany. ncmkie@uniklinik-saarland.de

Abstract

The objective of this prospective study was to find outcome predictors for better selection for treatment of normal-pressure hydrocephalus (NPH) patients. A total of 125 patients were evaluated and provided with a gravitational shunt. Cerebrospinal fluid hydrodynamics provided better predictive values if an algorithm to shunt all patients with a pressure/volume index of < 30 mL or resistance to outflow > 13 mmHg/mL x min was used. In general, outcome became worse with increasing anamnesis duration, worse preoperative clinical state, and increasing comorbidity. If one of these parameters was lower than a critical value, the shunt-responder rate was about 90% and the normally negative influence of older age was not seen. The well-known paradigm of a worse prognosis with NPH is not the result of the hydrocephalus etiology itself, but the consequence of a typical accumulation of negative outcome predictors as a consequence of the misinterpretation of normal aging and delayed adequate treatment.

PMID:
16671486
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center