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J Psychosom Res. 2006 May;60(5):545-7.

Kissing selectively decreases allergen-specific IgE production in atopic patients.

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Department of Allergy, Satou Hospital, 65-1 Yabuhigashimachi, Hirakata-City, Osaka Prefecture 573-1124, Japan.



Stress enhanced allergic skin wheal responses and allergen-specific IgE production. In contrast, mothers' kissing caused relaxation in infants, and kissing by lovers or spouses to atopic patients reduced allergic skin wheal responses. I studied the effect of kissing on production of allergen-specific IgE and cytokines in atopic patients.


Twenty-four patients with mild atopic eczema and 24 patients with mild allergic rhinitis kissed with lovers or spouses freely for 30 min while listening to soft music. Just before and immediately after kissing, blood mononuclear cells were separated cultured for allergen, and production of allergen-specific immunoglobulin and cytokine was measured.


Kissing selectively decreased allergen-specific IgE production with skewing cytokine pattern toward Th1 type.


Kissing may alleviate allergic symptoms by decrease in allergen-specific IgE production.

[Indexed for MEDLINE]

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