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Pediatr Dermatol. 2006 Mar-Apr;23(2):132-5.

Endemic pemphigus foliaceus in Venezuela: report of two children.

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Department of Dermatology, Hospital Universitario de Caracas, Luis Razetti School of Medicine, Central University of Venezuela, Caracas, Venezuela.


Two native Yanomami children from the Venezuelan Amazonia with erythroderma were hospitalized on our service. Clinical, histologic, and immunofluorescence studies diagnosed endemic pemphigus foliaceous. Human leukocyte antigen class II showed DRB1*04 subtype *0411, which has not been previously associated with this disease. However, it shares a common epitope with all the human leukocyte antigen DRB1 alleles that have been involved in this disease among Brazilian populations. Although this condition is endemic in Brazil, our patients are the first two reported in Venezuela.

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