Format

Send to

Choose Destination
Cell Mol Life Sci. 2006 Jun;63(11):1278-93.

Re-creating an RNA world.

Author information

1
Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA. ufmuller@ucsd.edu

Abstract

The RNA world hypothesis states that life originated via a system based on RNA genomes and RNA catalysts. Researchers have been trying to develop such a system since catalytic RNAs (ribozymes) were discovered in 1982. This review summarizes the recent progress made in that endeavor and outlines the obstacles that remain to be overcome. After giving a short background on prebiotic chemistry and in vitro evolution, the discussion focuses on the generation of three important components of an RNA world: a sufficient polymerase ribozyme, self-replicating membrane compartments and ribozymes that are capable of performing basic metabolic processes.

PMID:
16649141
DOI:
10.1007/s00018-006-6047-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center