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Am J Psychiatry. 2006 May;163(5):927-9.

Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia.

Author information

1
New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA.

Abstract

OBJECTIVE:

In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring.

METHOD:

The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled.

RESULTS:

Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness.

CONCLUSIONS:

Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.

PMID:
16648337
DOI:
10.1176/ajp.2006.163.5.927
[Indexed for MEDLINE]

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