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Am J Obstet Gynecol. 2006 Aug;195(2):504-9. Epub 2006 May 2.

Inhibitory effect of leptin on human uterine contractility in vitro.

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1
Department of Obstetrics and Gynaecology, Clinical Science Institute, University College Hospital Galway, National University of Ireland, Galway, Ireland.

Abstract

OBJECTIVE:

The purpose of this study was to investigate the effects of leptin on human uterine contractility in vitro.

STUDY DESIGN:

Biopsies of human myometrium were obtained at elective cesarean section (n = 18). Dissected myometrial strips suspended under isometric conditions, undergoing spontaneous and oxytocin-induced contractions, were exposed to cumulative additions of leptin in the concentration range of 1 nmol/L to 1 micromol/L. Control strips were run simultaneously. Integrals of contractile activity were measured using the PowerLab hardware unit and Chart v3.6 software.

RESULTS:

Leptin exerted a potent and cumulative inhibitory effect on spontaneous and oxytocin-induced contractions compared to control strips. The mean maximal inhibition values were as follows: 46.794 +/- 5.133% (n = 6; P < .001) for spontaneous contractions and 42.323 +/- 3.692% (n = 6; P < .001) for oxytocin-induced contractions. There was an apparent reduction in both frequency and amplitude of contractions.

CONCLUSION:

This physiologic inhibitory effect of leptin on uterine contractility may play a role in the dysfunctional labor process associated with maternal obesity, and the resultant high cesarean section rates.

PMID:
16647683
DOI:
10.1016/j.ajog.2006.01.106
[Indexed for MEDLINE]
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