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Otolaryngol Head Neck Surg. 2006 May;134(5):783-7.

Evaluation of super-high-dose steroid therapy for sudden sensorineural hearing loss.

Author information

1
Department of Otorhinolaryngology, Saitama Medical Center, Saitama Medical School, Saitama, Japan.

Abstract

OBJECTIVE:

To determine the efficacy of a high-dose steroid regimen for patients with sudden sensorineural hearing loss (SSNHL) and to evaluate the relationship between outcome and initial steroid dose.

STUDY DESIGN AND SETTING:

We conducted a retrospective study of 112 patients presenting to Saitama Medical Center. Patients received tapering courses of hydrocortisone (HC) with an initial dose of either 1200 mg or 600 mg.

RESULTS:

More than 87% of patients had recovery of hearing. When hearing stabilized, there were no significant differences between the 1200 mg and 600 mg groups in terms of hearing outcome (P>0.05). However, at completion of treatment, the 1200 mg group exhibited significantly superior complete recovery rate and improvement rate (P<0.05).

CONCLUSION:

Application of our treatment protocol of a tapered course of 1200 mg HC significantly and rapidly improves recovery outcomes in patients of SSNHL.

EBM RATING:

C-4.

PMID:
16647535
DOI:
10.1016/j.otohns.2005.12.029
[Indexed for MEDLINE]
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