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Int J Antimicrob Agents. 2006 May;27(5):359-66. Epub 2006 Apr 27.

Candidaemia in Europe: epidemiology and resistance.

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Istituto di Igiene e Medicina Preventiva, Università degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy.


Despite the widespread use of antifungals for prophylaxis, Candida bloodstream infection (BSI) remains the most frequent life-threatening fungal disease. From an analysis of multi-institutional surveys of Candida BSIs performed in Europe, including the large prospective survey by the European Confederation of Medical Mycology (2089 episodes from seven countries), a limited role of species with decreased susceptibility to azoles in causing BSIs and a low proportion of antifungal resistance was evident. Large prospective epidemiological surveys using common databases are needed to monitor trends in incidence and changes in species distribution, to identify new at-risk patients and to evaluate the impact of the introduction into the market of new antifungal agents.

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