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Mol Cell Endocrinol. 2006 Jun 27;252(1-2):102-6. Epub 2006 Apr 27.

Meiotic arrest of oocytes depends on cell-to-cell communication in the ovarian follicle.

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Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.


The source of the inhibitory levels of cAMP that maintain oocytes meiotically arrested is under controversy. A model for regulation of the meiotic division that suggests the transfer of a somatic follicular cells-derived cAMP into the oocyte via gap junctions was first proposed by us in 1978. Later studies provide strong evidence that established gap-junctional communication within the ovarian follicle is indispensable for maintenance of meiotic arrest. On the other hand, other recent reports suggest that oocytes generate their own inhibitory cAMP by a G protein-coupled receptor-activated Gs. These studies as well as other recent reports related to this topic are thoroughly discussed in this chapter.

[Indexed for MEDLINE]

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