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Stat Appl Genet Mol Biol. 2002;1:Article1. Epub 2002 Aug 22.

Pre-validation and inference in microarrays.

Author information

1
Stanford University, USA. tibs@stat.stanford.edu

Abstract

In microarray studies, an important problem is to compare a predictor of disease outcome derived from gene expression levels to standard clinical predictors. Comparing them on the same dataset that was used to derive the microarray predictor can lead to results strongly biased in favor of the microarray predictor. We propose a new technique called "pre-validation'' for making a fairer comparison between the two sets of predictors. We study the method analytically and explore its application in a recent study on breast cancer.

PMID:
16646777
DOI:
10.2202/1544-6115.1000

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