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Epidemiol Prev. 2005 Sep-Dec;29(5-6 Suppl):91-5.

[Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project].

[Article in Italian]

Author information

1
Struttura di cancerogenesi ambientale, Istituto nazionale per la ricerca sul cancro, Genova. claudia.bolognesi@istge.it

Abstract

OBJECTIVE:

To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs.

DESIGN:

Molecular epidemiology study.

SETTING:

S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs.

PARTICIPANTS:

50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits.

MAIN OUTCOME MEASURES:

Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2).

RESULTS:

19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups.

CONCLUSION:

This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.

PMID:
16646270
[Indexed for MEDLINE]
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