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Dement Geriatr Cogn Disord. 2006;21(5-6):392-402. Epub 2006 Apr 25.

Brief informant screening test for mild cognitive impairment and early Alzheimer's disease.

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1
Gerontological Research Programme, Department of Psychological Medicine, National University of Singapore, Singapore.

Abstract

BACKGROUND/AIMS:

Recent research has attempted combinations of instruments to improve screening accuracy for mild cognitive impairment (MCI) and early Alzheimer's disease (AD). We compared Mini-Mental State Examination (MMSE), Immediate and Delayed Recall (Logical Memory I and II; LM-I and LM-II, respectively), a single-item informant report of memory problem (IRMP), and a four-item Instrumental Activities of Daily Living (4IADL) scale, and combinations of these tests.

METHOD:

The tests were administered together with Clinical Dementia Rating (CDR) to subjects who were cognitively intact (CDR = 0, n = 88), and with diagnoses of MCI (CDR = 0.5, n = 37) and early AD (CDR = 1-2, n = 19).

RESULTS:

Screening accuracy (receiver operating characteristic area under curve, AUC) for identifying MCI or MCI-AD was lowest for MMSE (AUC 67.6% for MCI or 77.9% for MCI-AD), and better for IRMP (79.5 or 83.2%), 4IADL (76.9 or 84.7%), LM-I (81.2 or 87.1%) and LM-II (86.1 or 90.8%). Combining IRMP, 4IADL and LM-II was most accurate (AUC 91.7% for MCI or 94.5% for MCI-AD); sensitivity: 86.5 or 89.3%; specificity: 86.4 or 88.6%. However, combining IRMP and 4IADL gave nearly as good accuracy (AUC 87.2 or 91.6%); sensitivity: 86.5 or 85.7%; specificity: 79.5 or 85.2%.

CONCLUSION:

A brief instrument combining an IRMP and 4IADL items is potentially useful in screening for MCI and early AD.

PMID:
16645272
DOI:
10.1159/000092808
[Indexed for MEDLINE]
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