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Protein Sci. 2006 May;15(5):1193-8.

Ligand binding by TPR domains.

Author information

1
Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut 06520, USA.

Abstract

Tetratricopeptide repeat (TPR) domains bind specific peptide ligands and are thought to mediate protein-protein interactions in a variety of biological systems. Here we compare peptide ligand-binding by several different TPR domains. We present specific examples that demonstrate that TPR domains typically undergo little or no structural rearrangement upon ligand binding. Our data suggest that, contrary to a recent proposal, coupled folding and binding is not the common mechanism of ligand recognition by TPR domains.

PMID:
16641492
PMCID:
PMC2242500
DOI:
10.1110/ps.062092506
[Indexed for MEDLINE]
Free PMC Article
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