Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen

Antimicrob Agents Chemother. 2006 May;50(5):1878-80. doi: 10.1128/AAC.50.5.1878-1880.2006.

Abstract

Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / blood
  • Antifungal Agents / pharmacokinetics*
  • Bronchoalveolar Lavage Fluid / chemistry
  • Bronchoscopy
  • Chromatography, High Pressure Liquid
  • Clinical Protocols
  • Epithelial Cells / metabolism
  • Female
  • Humans
  • Lung / metabolism*
  • Lung Diseases, Fungal / prevention & control*
  • Male
  • Middle Aged
  • Pilot Projects
  • Pleura / metabolism
  • Prospective Studies
  • Pyrimidines / administration & dosage
  • Pyrimidines / blood
  • Pyrimidines / pharmacokinetics*
  • Reference Standards
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Triazoles / administration & dosage
  • Triazoles / blood
  • Triazoles / pharmacokinetics*
  • Urea / blood
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Urea
  • Voriconazole