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Antimicrob Agents Chemother. 2006 May;50(5):1701-9.

7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.

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1
Division of Microbiology, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany.

Abstract

We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.

PMID:
16641438
PMCID:
PMC1472237
DOI:
10.1128/AAC.50.5.1701-1709.2006
[Indexed for MEDLINE]
Free PMC Article
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