Format

Send to

Choose Destination
J Med Chem. 2006 May 4;49(9):2841-4.

Synthesis of biphenyltrienes as probes for beta-amyloid plaques.

Author information

1
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

We report a series of p-hydroxy-, p-amino-, p-monomethylamino-, and p-monofluoroethylamino-substituted biphenyltrienes that displayed high binding affinities to beta-amyloid plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheimer's patients and [(125)I]9, the triene compounds showed excellent binding affinities. When labeled with suitable radionuclides, they are useful as in vivo imaging agents for detecting Abeta plaques in the brains of Alzheimer's patients.

PMID:
16640346
PMCID:
PMC2597440
DOI:
10.1021/jm051020k
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center