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Drug Discov Today. 2006 May;11(9-10):391-404.

Antibacterial drug discovery and structure-based design.

Author information

1
Evotec UK, 111 Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK. john.barker@evotec.com

Abstract

Bacterial resistance continues to develop and pose a significant threat, both in hospitals and, more recently, in the community. A focus on other therapeutic areas by the larger pharmaceutical companies has left a shortfall in the pipeline of novel antibacterials. Recently, many new structures have been studied by structure-genomics initiatives, delivering a wealth of targets to consider. Using the tools of structure-based design, antibacterial discovery must exploit these targets to accelerate the process of drug discovery.

PMID:
16635801
DOI:
10.1016/j.drudis.2006.03.001
[Indexed for MEDLINE]
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