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J Am Acad Dermatol. 2006 May;54(5):899-902.

Aquagenic syringeal acrokeratoderma: report of a case with histologic findings.

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Division of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa, Florida 33612, USA.


Aquagenic syringeal acrokeratoderma is a rare acquired condition characterized by painful symmetric swelling and hypopigmentation of the palms and lateral fingers, which develops after brief exposure to water. Histopathologic examination suggests that an aberration in the eccrine sweat gland apparatus may be the underlying cause of this condition. The "hand-in-the-bucket sign," in which patients arrive in their physician's office with their hand in a bucket of water to more readily demonstrate their lesions, is such a common presentation that it almost can be regarded as pathognomonic. All 12 cases reported to date have been in young females. We report a case of aquagenic syringeal acrokeratoderma in a male with unique histologic findings.

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