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Lung Cancer. 2006 Jun;52(3):291-7. Epub 2006 Apr 25.

Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer.

Author information

1
Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis, Cancer Center and Northern California VA Health System, 4501 X Street, Sacramento, CA 95817, USA. derick.lau@ucdmc.ucdavis.edu

Abstract

Lung cancer is one of the most common cancers and is the leading cause of cancer death. We wish to identify peptide ligands for unique cell surface receptors of non-small lung cancer with the hope of developing these ligands as diagnostic and therapeutic agents. Using the method of 'one-bead one-peptide' combinatorial chemistry, a library of random cyclic octapeptides was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment of lung adenocarcinoma cells employing a 'cell-growth-on-bead' assay. Consensus peptide sequences of cNGXGXXc were identified. These peptides promoted cell adhesion by targeting integrin alpha3beta1 over-expressed in non-small lung cancer cells. These peptide beads can be applied to capture cancer cells in malignant pleural fluid for purpose of diagnosis of lung cancer.

PMID:
16635537
DOI:
10.1016/j.lungcan.2006.03.003
[Indexed for MEDLINE]

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