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Lung Cancer. 2006 Jun;52(3):291-7. Epub 2006 Apr 25.

Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer.

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Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis, Cancer Center and Northern California VA Health System, 4501 X Street, Sacramento, CA 95817, USA.


Lung cancer is one of the most common cancers and is the leading cause of cancer death. We wish to identify peptide ligands for unique cell surface receptors of non-small lung cancer with the hope of developing these ligands as diagnostic and therapeutic agents. Using the method of 'one-bead one-peptide' combinatorial chemistry, a library of random cyclic octapeptides was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment of lung adenocarcinoma cells employing a 'cell-growth-on-bead' assay. Consensus peptide sequences of cNGXGXXc were identified. These peptides promoted cell adhesion by targeting integrin alpha3beta1 over-expressed in non-small lung cancer cells. These peptide beads can be applied to capture cancer cells in malignant pleural fluid for purpose of diagnosis of lung cancer.

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