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Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.

VEGF receptor signalling - in control of vascular function.

Author information

1
Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjöldv. 20, 751 85 Uppsala, Sweden.

Abstract

Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.

PMID:
16633338
DOI:
10.1038/nrm1911
[Indexed for MEDLINE]

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