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Endocrinol Metab Clin North Am. 2006 Jun;35(2):357-69, x.

Genes of type 2 diabetes in beta cells.

Author information

1
Experimental Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.

Abstract

Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.

PMID:
16632098
DOI:
10.1016/j.ecl.2006.02.008
[Indexed for MEDLINE]

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